nelsonlab stanford.edu

W. James Nelson Lab Homepage at Stanford University

Our research objectives are to understand cellular mechanisms involved in development and maintenance of cell polarity. Recent studies indicate that development of epithelial cell polarity is a multistage process requiring instructive extracellular cues eg. cell-cell and cell-substratum contact and reorganization of proteins in the cytoplasm and on the plasma membrane. Once established, polarity is maintained by targeting and retention of proteins to functionally distinct apical and basal-lateral plasma m

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The Nachury Lab - Home

We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to. 8203; obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand. How trafficking shapes signaling at the primary cilium, we leverage. A broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution.

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W. James Nelson Lab Homepage at Stanford University

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Our research objectives are to understand cellular mechanisms involved in development and maintenance of cell polarity. Recent studies indicate that development of epithelial cell polarity is a multistage process requiring instructive extracellular cues eg. cell-cell and cell-substratum contact and reorganization of proteins in the cytoplasm and on the plasma membrane. Once established, polarity is maintained by targeting and retention of proteins to functionally distinct apical and basal-lateral plasma m

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